Greenland sharks may help us cure cancer
A cure for cancer may be swimming 2,200 meters (~7,200 feet) below the surface of the Arctic and North Atlantic oceans. Greenland sharks (Somniosus microcephalus) are deep-dwelling animals who live to be ~400 years old in the wild without a shred of medical care. The secret to their longevity is likely in their genes that fend off cancer.
An international team of 28 scientists recently published a paper mapping the Greenland shark’s genome. And the results are astonishing. The shark’s genome has two remarkable features: many duplicate genes give the shark an enhanced ability to repair damaged DNA and their genome has an altered p53 protein that makes the protein more robust. What do those two things have to do with cancer? As it turns out, everything!
Damaged DNA and cancer
Damaged DNA that isn’t repaired causes mutations in genes that regulate how a cell grows and divides. This damage causes cell growth to skyrocket uncontrollably leading to tumors, a.k.a. cancer. There are many ways DNA can be damaged — UV rays from the sun when we don’t wear sufficient sunscreen, tobacco smoke, exposure to toxic chemicals, aging, and the normal processes of living.
Most of the time and for most of our lives, our bodies recognize the damaged DNA and either repair the cell or purge that cell through our natural waste processes, kicking the damaged cell out of our bodies so it never causes problems. However, these damaged cells can be sneaky and hide or the amount of damage can be very extensive, making it difficult for our bodies to repair or remove all of it.
The Greenland shark’s enhanced ability to repair damaged DNA is an incredible adaptation that helps prevent cancer. Knowing that DNA damage is such an asset for the shark’s longevity further spurs our cancer research to seek out new treatments and therapies to enhance human abilities to repair DNA damage.
p53 protein and cancer
The p53 protein is a powerhouse in the bodies of almost every animal. p53 is a tumor suppressor, protecting cell DNA from damage, initiating repairs when it detects damaged DNA, and kicking damaged cell out of the body when necessary. Greenland sharks have a more robust p53 protein than other animals, allowing them to be more highly attuned to protect against and repair DNA damage.
Biomimicry, nature preservation, and biodiversity conservation is vital for human health
Among its many attributes, nature is a research lab, pharmacy, library, and archive. The species with whom we share this planet hold the answers to every question we have. It takes time, effort, and funding to study nature and find these answers.
By employing biomimicry (the emulation of nature’s design genius, such as the adaptations of the Greenland sharks that give them such great longevity), protecting nature, and safeguarding biodiversity, we are providing ourselves with a source of unlimited creativity, knowledge, and wisdom. Our lives, and the lives of all beings, are intricately intertwined. Nature will help us thrive if we care enough to help nature survive.